Sodium Hydroxide → Ibandronate Sodium Anhydrous

HRID 229927Notes

Reaction equation

HRID 229927 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([OH:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[OH-].[Na+:21]>O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([O-:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[Na+:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 60852Ibandronate

Product 1

HCID 23670359Ibandronate Sodium AnhydrousYield 104.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of amorphous ibandronic acid (5 g) in water (50 ml) was heated to reflux temperature. Solid sodium hydroxide (0.63 g) was added, and the reaction mixture was stirred at reflux temperature for an additional 1 hour. Then the reaction mixture was cooled to room temperature. The clear solution was evaporated to give 5.6 g of amorphous ibandronate sodium.

Workup

  1. temperatureto reflux temperature
  2. temperatureat reflux temperature for an additional 1 hour
  3. customThe clear solution was evaporated

Sources & evidence

ORD record
ord-46ac83571fee44c29a537ef83ecdcc7a
Source dataset
uspto-grants-2009_07
Patent number
US07563918B2

Reaction notes

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