HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ibandronate Sodium Anhydrous
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ibandronate | HCID 60852 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ibandronate Sodium Anhydrous | HCID 23670359 | 104.8% |
Reaction Steps
A solution of amorphous ibandronic acid (5 g) in water (50 ml) was heated to reflux temperature. Solid sodium hydroxide (0.63 g) was added, and the reaction mixture was stirred at reflux temperature for an additional 1 hour. Then the reaction mixture was cooled to room temperature. The clear solution was evaporated to give 5.6 g of amorphous ibandronate sodium.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563918B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-46ac83571fee44c29a537ef83ecdcc7a |
| Source note | uspto-grants-2009_07 |