Sodium Hydroxide → Ibandronate Sodium Anhydrous

HRID 229928Notes

Reaction equation

HRID 229928 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([OH:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[OH-].[Na+:21]>C(#N)C>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:8][CH2:9][C:10]([P:16]([O-:19])([OH:18])=[O:17])([P:12]([OH:15])([OH:14])=[O:13])[OH:11])[CH3:7].[Na+:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 60852Ibandronate

Product 1

HCID 23670359Ibandronate Sodium AnhydrousYield 93.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A slurry of amorphous ibandronic acid (5 g) in acetonitrile (50 ml) was stirred at room temperature. Solid sodium hydroxide (0.63 g) was added, and the reaction mixture was stirred at room temperature for an additional 72 hours. The precipitate was isolated by vacuum filtration and dried in a vacuum oven at 50° C. for 20 hours to obtain 5.0 g of amorphous ibandronate sodium.

Workup

  1. customThe precipitate was isolated by vacuum filtration
  2. customdried in a vacuum oven at 50° C. for 20 hours

Sources & evidence

ORD record
ord-5e7eaeb7f2a24e5680eedcdee516bfb4
Source dataset
uspto-grants-2009_07
Patent number
US07563918B2

Reaction notes

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