Sodium Hydroxide → Ibandronate Sodium Anhydrous

Participants

Reaction Steps

A slurry of amorphous ibandronic acid (5 g) in acetonitrile (50 ml) was stirred at room temperature. Solid sodium hydroxide (0.63 g) was added, and the reaction mixture was stirred at room temperature for an additional 72 hours. The precipitate was isolated by vacuum filtration and dried in a vacuum oven at 50° C. for 20 hours to obtain 5.0 g of amorphous ibandronate sodium.

Provenance & Evidence