2-Chloropropionic acid → HCID 15484845, compound

HRID 2299531Notes

Reaction equation

HRID 2299531 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([F:9])[CH:8]=1)[NH2:5].Cl[CH:11]([CH3:15])[C:12]([OH:14])=[O:13]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][CH:11]([C:12]([OH:14])=[O:13])[CH3:15])[CH:6]=[C:7]([F:9])[CH:8]=1

Participants

3

Reactant 2

HCID 117342-Chloropropionic acidHCID 965953,5-Difluoroaniline

Product 1

HCID 15484845HCID 15484845, compound

Procedure

Using the procedure set forth in U.S. Pat. No. 3,598,859 (or Example A above), N-(3,5-difluorophenyl)-D,L-alanine was prepared using 3,5-difluoroaniline (Aldrich) and 2-chloropropionic acid (Aldrich).

Sources & evidence

ORD record
ord-3993b5f7633d41ca9ab51bd03e373fa4
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Reaction notes

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