N-(3,4-dichlorophenyl)glycine → HCID 53814239, compound

HRID 2299547Notes

Reaction equation

HRID 2299547 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][CH2:10][C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:15][O:16][C:17](=[O:23])[C@H:18]([CH2:20][CH2:21][CH3:22])[NH2:19]>>[CH3:15][O:16][C:17](=[O:23])[C@@H:18]([NH:19][C:11](=[O:13])[CH2:10][NH:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:20][CH2:21][CH3:22]

Participants

3

Reactant 2

HCID 351250N-(3,4-dichlorophenyl)glycineHCID 14118488methyl (2S)-2-aminopentanoate hydrochloride

Product 1

HCID 53814239HCID 53814239, compound

Procedure

Following General Procedure D and using N-(3,4-dichlorophenyl)glycine (from Example I above) and L-norvaline methyl ester hydrochloride (Sennchem), the title compound was prepared. The reaction was monitored by tlc (Rf=0.32 in 50% ethyl acetate/hexanes) and purification was by silica gel chromatography using ethyl acetate/hexanes as the eluent.

Workup

  1. customThe reaction was monitored by tlc (Rf=0.32 in 50% ethyl acetate/hexanes) and purification

Sources & evidence

ORD record
ord-eaf20c55e66447139ce0eb0b70eb102a
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Reaction notes

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