HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Alanine → HCID 18341177, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Alanine | HCID 5950 | — |
| Reactant | 2-(3,4-Dichloro-phenylamino)-propionic Acid | HCID 6916426 | — |
| Reactant | Methyl 3-cyclohexyl-L-alaninate | HCID 13833920 | — |
| Product | HCID 18341177 | HCID 18341177 | — |
Reaction Steps
Following General Procedure D and using 3-cyclohexylalanine methyl ester (prepared from β-cyclohexylalanine (Bachem) using General Procedure K) and N-(3,4-dichlorophenyl)-D,L-alanine, the title compound, as a mixture of diastereomers about alanine, was prepared as an oil. The reaction was monitored by tlc (Rf=0.27 (second isomer) and 0.30 (first isomer) in 35% EtOAc/hexanes) and purification was by flash chromatography (35% EtOAc/hexanes).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495693B2 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-1f2f0e2671de4d1bacf391c2f2326216 |
| Source note | uspto-grants-2002_12 |