Alanine methyl ester hydrochloride → HCID 54367074, compound

HRID 2299557Notes

Reaction equation

HRID 2299557 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:8])[C@H:5]([CH3:7])[NH2:6].[F:9][C:10]1[CH:11]=[C:12]([NH:17][CH:18]([C:20](O)=[O:21])[CH3:19])[CH:13]=[C:14]([F:16])[CH:15]=1>>[CH3:2][O:3][C:4](=[O:8])[C@H:5]([CH3:7])[NH:6][C:20](=[O:21])[CH:18]([CH3:19])[NH:17][C:12]1[CH:13]=[C:14]([F:16])[CH:15]=[C:10]([F:9])[CH:11]=1

Participants

3

Reactant 2

HCID 2733257Alanine methyl ester hydrochlorideHCID 15484845HCID 15484845, compound

Product 1

HCID 54367074HCID 54367074, compound

Procedure

Following General Procedure E and using L-alanine methyl ester hydrochloride (Sigma) and N-(3,5-difluorophenyl)-D,L-alanine (from Example C above), the title compound was prepared as a solid (mp=93-95° C.). The reaction was monitored by tlc (Rf=0.4 in 3% methanol/methylene chloride) and purification of this compound was by flash chromatography with 3% methanol/methylene chloride.

Workup

  1. customThe reaction was monitored by tlc (Rf=0.4 in 3% methanol/methylene chloride) and purification of this compound

Sources & evidence

ORD record
ord-d78a13f409a444d3a1a7a98dcf771f90
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Reaction notes

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