Thionyl Chloride → HCID 15450534, compound

HRID 2299572Notes

Reaction equation

HRID 2299572 reaction equation
[C:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]2[S:9][CH:10]=[C:11]([C:12](O)=[O:13])[C:7]=2[CH:6]=1)(=[O:3])[CH3:2].S(Cl)([Cl:19])=O>CN(C)C=O.C1(C)C=CC=CC=1>[C:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]2[S:9][CH:10]=[C:11]([C:12]([Cl:19])=[O:13])[C:7]=2[CH:6]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 15450533HCID 15450533, compound

Product 1

HCID 15450534HCID 15450534, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 1140TolueneSolvent

Procedure

5-Acetoxybenzo[b]thiophene-3-carboxylic acid (12) (1,349 mg) prepared above was refluxed for 1.5 hours with dimethylformamide (1 drop), thionyl chloride (1.22 ml) and toluene (25 ml). The solvent was removed under reduced pressure to provide 1,454 mg of the title compound (13).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a82b9114682547eea7a6201839acf3b2
Source dataset
uspto-grants-2002_12
Patent number
US06495702B2

Reaction notes

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