Hydrochloric Acid → HCID 69329976, compound

HRID 2299677Notes

Reaction equation

HRID 2299677 reaction equation
[CH2:1]([O:3][C:4]1[CH:40]=[CH:39][C:7]2[CH2:8][CH2:9][CH2:10][CH:11]([N:13](C(OC(C)(C)C)=O)[CH2:14][C@H:15]([O:24][Si](CC)(CC)CC)[CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][C:6]=2[CH:5]=1)[CH3:2].[ClH:41]>CO>[ClH:41].[CH2:1]([O:3][C:4]1[CH:40]=[CH:39][C:7]2[CH2:8][CH2:9][CH2:10][CH:11]([NH:13][CH2:14][C@H:15]([OH:24])[CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][C:6]=2[CH:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57134119HCID 57134119, compound

Product 1

HCID 69329976HCID 69329976, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-(3-ethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)-N-[(2S)-3-phenoxy-2-(triethylsilyloxy)propyl]-tert-butoxycarbonylamine (115 mg) and concentrated hydrochloric acid (0.5 ml) in methanol (5 ml) was stirred at room temperature for 48 hours. The mixture was evaporated in vacuo. The residue was triturated with diethyl ether-diisopropyl ether, followed by decantation and dryness in vacuo to give (2S)-1-(3-ethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino-3-phenoxy-2-propanol hydrochloride (30 mg).

Workup

  1. customThe mixture was evaporated in vacuo
  2. customThe residue was triturated with diethyl ether-diisopropyl ether

Sources & evidence

ORD record
ord-786aab4863e349c39c3cd969e5dc14d3
Source dataset
uspto-grants-2002_12
Patent number
US06495546B1

Reaction notes

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