Hydrochloric Acid → HCID 18340060, compound

HRID 2299688Notes

Reaction equation

HRID 2299688 reaction equation
[ClH:1].[OH:2][C@H:3]([CH2:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:4][NH:5][CH:6]1[CH2:12][C:11]2[CH:13]=[C:14]([CH2:17][NH:18]C(=O)C)[CH:15]=[CH:16][C:10]=2[CH2:9][CH2:8][CH2:7]1.Cl>>[ClH:1].[ClH:1].[NH2:18][CH2:17][C:14]1[CH:15]=[CH:16][C:10]2[CH2:9][CH2:8][CH2:7][CH:6]([NH:5][CH2:4][C@H:3]([OH:2])[CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:12][C:11]=2[CH:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18340079HCID 18340079, compound

Product 1

HCID 18340060HCID 18340060, compoundYield 190.5%

Procedure

A mixture of N-[8-[(2S)-2-hydroxy-3-phenoxypropyl]amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl]methyl acetamide hydrochloride (100 mg) and 1N aqueous hydrochloric acid solution (2 ml) was heated to reflux for 18 hours. The solvent was removed under reduced pressure to dryness. The residue was triturated in diisopropyl ether, and the precipitated powder was collected by fIltration to afford (2S)-1-[(3-aminomethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol dihydrochloride (94 mg).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours
  3. customThe solvent was removed under reduced pressure to dryness
  4. customThe residue was triturated in diisopropyl ether
  5. filtrationthe precipitated powder was collected by fIltration

Sources & evidence

ORD record
ord-935c7c8042d441e9bbce4da5603dcca0
Source dataset
uspto-grants-2002_12
Patent number
US06495546B1

Reaction notes

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