HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]phthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | N-Hydroxyphthalimide | HCID 10665 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(4-Chloromethylphenoxy)methyl-5-methyl-2-phenyloxazole | HCID 10946940 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]phthalimide | HCID 22344648 | 93% |
Reaction Steps
A mixture of 4-(4-chloromethylphenoxymethyl)-5-methyl-2-phenyloxazole (5.00 g), N-hydroxyphthalimide (2.59 g), potassium carbonate (4.40 g) and N,N-dimethylformamide (50 ml) was stirred at room temperature for 20 hours, and water (500 ml) was added. The resultant crystals were filtered, and washed with water to obtain N-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]phthalimide (6.49 g, yield 93%) as colorless crystals. m.p. 155-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06495581B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-887e203ce33a4cb2bba2ce5785c7946a |
| Source note | uspto-grants-2002_12 |