Dimethylformamide → N-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]phthalimide

HRID 2299723Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2299723
Cl[CH2:2][C:3]1[CH:22]=[CH:21][C:6]([O:7][CH2:8][C:9]2[N:10]=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:12][C:13]=2[CH3:14])=[CH:5][CH:4]=1.[OH:23][N:24]1[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]2[C:25]1=[O:34].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[CH3:14][C:13]1[O:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:10][C:9]=1[CH2:8][O:7][C:6]1[CH:21]=[CH:22][C:3]([CH2:2][O:23][N:24]2[C:25](=[O:34])[C:26]3=[CH:33][CH:32]=[CH:31][CH:30]=[C:27]3[C:28]2=[O:29])=[CH:4][CH:5]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 10665N-HydroxyphthalimideHCID 11430Potassium CarbonateHCID 109469404-(4-Chloromethylphenoxy)methyl-5-methyl-2-phenyloxazole

Produkt 1

HCID 22344648N-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]phthalimideAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 4-(4-chloromethylphenoxymethyl)-5-methyl-2-phenyloxazole (5.00 g), N-hydroxyphthalimide (2.59 g), potassium carbonate (4.40 g) and N,N-dimethylformamide (50 ml) was stirred at room temperature for 20 hours, and water (500 ml) was added. The resultant crystals were filtered, and washed with water to obtain N-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]phthalimide (6.49 g, yield 93%) as colorless crystals. m.p. 155-156° C.

Aufarbeitung

  1. filtrationThe resultant crystals were filtered
  2. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-887e203ce33a4cb2bba2ce5785c7946a
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06495581B1

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