反应详情

4-{[4-(4-fluorobenzyloxy)-phenyl]-(3-methyl-butyl)-amino}-piperidine-1-carboxylic acid tert-butyl ester (If, 1.80 g, 3.82 mmol) was dissolved in CH2Cl2 (12 mL), treated with TFA (12 mL), and stirred for 20 minutes. The reaction was concentrated and placed under vacuum for 20 minutes, then diluted with EtOAc (200 mL), washed twice with saturated sodium bicarbonate solution and once with brine, dried over Na2SO4, and concentrated to give 0.89 g (74%) of the desired product.

1. concentrationThe reaction was concentrated
2. waitplaced under vacuum for 20 minutes
3. additiondiluted with EtOAc (200 mL)
4. washwashed twice with saturated sodium bicarbonate solution and once with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated