反应详情

Diethylamine (69.2 g, 0.672 moles) was added dropwise at 5-10° C. to a solution of 3-cyclopentyloxy-4-methoxy benzoyl chloride (57 g, 0.224 moles) obtained as described in example 2, in methylene chloride (250 ml). The mixture was evaporated to dryness, dissolved in ethyl acetate, washed with water, with 2% potassium bisulphate, again with water and sodium bicarbonate, dried on sodium sulphate and brought to dryness. The residue was taken up with petrolatum (250 ml) to give 61.2 g of the title compound (yield: 94%).

1. customobtained
2. customThe mixture was evaporated to dryness
3. dissolutiondissolved in ethyl acetate
4. washwashed with water, with 2% potassium bisulphate, again with water and sodium bicarbonate
5. customdried on sodium sulphate