反应详情

A suspension of 204 mg of the mixture of 2-methanesulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one and 2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one in 1 mL of aniline was heated at reflux for 10 minutes resulting in a dark brown solution. Upon cooling to room temperature, a solid formed. Ethyl acetate was added, and the solid was collected by filtration, washed with ethyl acetate, then suspended in methanol and filtered, and washed with additional methanol to provide 175 mg of 2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one, mp>350° C.

1. temperaturewas heated
2. temperatureat reflux for 10 minutes
3. customresulting in a dark brown solution
4. customa solid formed
5. filtrationthe solid was collected by filtration
6. washwashed with ethyl acetate
7. filtrationfiltered
8. washwashed with additional methanol