反应详情

To a solution of 1.09 g (4.76 mmol) of the product from Example 224 Step A in 7 mL of carbon tetrachloride was added 847 mg (4.76 mmol) of N-bromosuccinimide and 78 mg (0.48 mmol) of 2,2′-azobisisobutyronitrile. The resultant mixture was heated at reflux for 2 5 hours, cooled to ambient temperature, diluted with carbon tetrachloride and filtered through celite. The filtrate was concentrated in vacuo and carried on without purification assuming 100% conversion. HPLC/MS (ESI) m/z (M+H)=310.9 (3.68 min).

1. temperatureat reflux for 2 5 hours
2. filtrationfiltered through celite
3. concentrationThe filtrate was concentrated in vacuo
4. customcarried on without purification
5. customHPLC/MS (ESI) m/z (M+H)=310.9 (3.68 min)