反应详情

9.11 g of tert-butyl 4-(2,3-dihydroxypropyl)-4-hydroxy-1-piperidinecarboxylate was dissolved in 40 ml pyridine, 10.0 g of chlorotriphenylmethane was added thereto, and the mixture was stirred at room temperature overnight. The reaction solution was partitioned into ethyl acetate and water, washed with 2 N hydrochloric acid, water, saturated aqueous sodium bicarbonate and brine, and dried over magnesium sulfate. After filtration, the solvent was evaporated, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give 10.3 g of tert-butyl 4-[3-(tert-butoxy)-2-hydroxypropyl]-4-hydroxy-1-piperidinecarboxylate.

1. customThe reaction solution was partitioned into ethyl acetate and water
2. washwashed with 2 N hydrochloric acid, water, saturated aqueous sodium bicarbonate and brine
3. dry with materialdried over magnesium sulfate
4. filtrationAfter filtration
5. customthe solvent was evaporated
6. customthe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate)