Ethyl Acetate → 3-Oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride

HRID 2300179ノート

反応式

HRID 2300179 の反応式
[O:1]=[C:2]1[CH2:6][C:5]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH2:4][O:3]1.[ClH:19].C(OCC)(=O)C.C(OCC)(=O)C>CO>[ClH:19].[O:1]=[C:2]1[CH2:6][C:5]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:4][O:3]1

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 21866389Hydrogen chloride-ethyl acetateHCID 22744536Tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

生成物 1

HCID 219553133-Oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1.16 g of tert-butyl 3-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate was dissolved in 2.3 ml methanol, 4.6 ml of 4 N hydrochloric acid/ethyl acetate was added thereto, and the mixture was stirred at room temperature for 1 hr. 5 ml ethyl acetate was added thereto, and the resulting crystals were collected by filtration to give 700 mg of 3-oxo-2-oxa-8-azaspiro[4.5]decane hydrochloride.

後処理

  1. filtrationthe resulting crystals were collected by filtration

出典と根拠

ORDレコード
ord-cad4471fb43a4d35819c7e2e545c791b
出典データセット
uspto-grants-2002_12
特許番号
US06498159B1

反応ノート

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