4-(Methylthio)phenylboronic acid → HCID 18376028, compound

HRID 2300193Notes

Reaction equation

HRID 2300193 reaction equation
Br[C:2]1[C:3]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[N:4][N:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12.[CH3:18][S:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:3]2[C:2]([C:23]3[CH:24]=[CH:25][C:20]([S:19][CH3:18])=[CH:21][CH:22]=3)=[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][N:5]3[N:4]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 27339594-(Methylthio)phenylboronic acidHCID 219486782-(4-Fluorophenyl)-3-bromopyrazolo[1,5-a]pyridine

Product 1

HCID 18376028HCID 18376028, compound

Procedure

By using 3-bromo-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine (4.0 g, 13.8 mmol) and 4-methylsulphanyl-phenylboronic acid (3.07 g, 1.83 mmol) the title compound was obtained as a white solid (2.29 g 50%) in the manner described in Example 2. MH+: 335; NMR: (CDCl3) δ 2.53 (3H, s) 6.80 (1H, t) 7.00 (2H, t) 7.15 (1H, t) 7.25 (2H, d) 7.30 (1H, d) 7.50 (2H, d) 7.60 (2H, m) 8.50 (1H, d).

Sources & evidence

ORD record
ord-6f783c609d0046c9a5fb356798b58bd9
Source dataset
uspto-grants-2002_12
Patent number
US06498166B1

Reaction notes

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