反应详情

To a solution of 4-butoxy-benzenesulfonic acid 4-(3-{[1-(4-butoxybenzene-sulfonyl)azetidin-3-yl]-tert-butoxycarbonyl-amino}-2-hydroxy-propoxy)-phenylester (0.12 g, 0.15 mmol) in dichloromethane (2 ml) was added trifluoroacetic acid (0.12 ml, 1.5 mmol). The mixture was stirred at room temperature for 4 h, and then quenched with saturated sodium carbonate solution and extracted with dichloromethane. The organic solution was washed with brine, dried over sodium sufate, and evaporated to give 0.10 g of a white solid; MS (ES) m/z 663.1 (MH+); HRMS (ES) Calcd. for C32H43N2O9S2 (MH+): 663.2410, Found: 663.2401.

1. customquenched with saturated sodium carbonate solution
2. extractionextracted with dichloromethane
3. washThe organic solution was washed with brine
4. dry with materialdried over sodium sufate
5. customevaporated