Propargylamine → HCID 22557994, compound

HRID 2300366Notes

Reaction equation

HRID 2300366 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][C:23](=O)[CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH2:27]([NH2:30])[C:28]#[CH:29]>>[CH2:27]([NH:30][CH:23]1[CH2:24][CH2:25][N:20]([CH2:19][C:17]2[CH:16]=[CH:15][N:14]=[C:13]([C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=2)[CH2:21][CH2:22]1)[C:28]#[CH:29]

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 22557811[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone

Product 1

HCID 22557994HCID 22557994, compound

Procedure

1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-4-piperidone (400 mg) and propargylamine (80 mg) were reacted in the same manner as described in Preparation Example 25 to give the title compound.

Workup

  1. customas described in Preparation Example 25

Sources & evidence

ORD record
ord-1b4845fe644e4be9a4fab3ebacf3e656
Source dataset
uspto-grants-2002_12
Patent number
US06498169B1

Reaction notes

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