3,5-Difluorophenylacetonitrile → 2-(3,5-Difluorophenylmethyl)-4-carboxy-2-thiazoline

HRID 23005Notes

Reaction equation

HRID 23005 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]#[N:11])[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.C([O:15][C:16](=[O:21])[C@H:17]([CH2:19][SH:20])N)C>>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]2[S:20][CH2:19][CH:17]([C:16]([OH:21])=[O:15])[N:11]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 5185653,5-DifluorophenylacetonitrileHCID 2723617Ethyl cysteinate hydrochloride

Product 1

HCID 225924872-(3,5-Difluorophenylmethyl)-4-carboxy-2-thiazoline

Procedure

Following General Procedure G and using 3,5-difluorophenylacetonitrile and L-cysteine ethyl ester hydrochloride (Aldrich), the title compound was prepared.

Sources & evidence

ORD record
ord-1aeed726105c4d6481478fa43013ccdb
Source dataset
uspto-grants-2005_02
Patent number
US06849650B2

Reaction notes

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