4'-Methoxyacetophenone → 1-(4-Methoxyphenyl)butane-1,3-dione

Participants

Reaction Steps

The title compound was prepared (as described above for Intermediate 16) from 3.0 g of 4′-methoxyacetophenone and 3.95 mL of EtOAc. Purification by recrystallization from toluene/hexane afforded the title compound: 1H NMR (400 MHz, CDCl3, enol form) δ7.70 (d, 2H, J=8.20), 7.34 (d, 2H, J=8.20), 6.17 (s, 1H), 3.87 (s, 3H), 2.17 (s, 3H); low resolution MS (ES)m/e 193.1 (MH+)

Provenance & Evidence