HCID 18374567, compound → HCID 12109773, compound

HRID 2300706Notes

Reaction equation

HRID 2300706 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[C:11](=[O:20])[CH:10]2[CH2:21][CH2:22][CH:23]([OH:30])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:5][CH:4]=1.[CH2:31]([C:35]1([CH2:73][CH3:74])[CH2:41][S:40](=[O:43])(=[O:42])[C:39]2[CH:44]=[CH:45][C:46]([N:48]([CH3:50])[CH3:49])=[CH:47][C:38]=2[CH:37]([C:51]2[CH:52]=[C:53]([NH:57][C:58]([CH2:60][O:61][CH2:62][CH2:63][O:64][CH2:65][CH2:66][O:67][CH2:68][C:69](O)=[O:70])=[O:59])[CH:54]=[CH:55][CH:56]=2)[CH:36]1[OH:72])[CH2:32][CH2:33][CH3:34]>ClCCl.CO>[CH2:31]([C:35]1([CH2:73][CH3:74])[CH2:41][S:40](=[O:43])(=[O:42])[C:39]2[CH:44]=[CH:45][C:46]([N:48]([CH3:50])[CH3:49])=[CH:47][C:38]=2[CH:37]([C:51]2[CH:52]=[C:53]([NH:57][C:58]([CH2:60][O:61][CH2:62][CH2:63][O:64][CH2:65][CH2:66][O:67][CH2:68][C:69]([NH:1][CH2:2][C:3]3[CH:8]=[CH:7][C:6]([CH:9]4[CH:10]([CH2:21][CH2:22][CH:23]([OH:30])[C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=5)[C:11](=[O:20])[N:12]4[C:13]4[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=4)=[CH:5][CH:4]=3)=[O:70])=[O:59])[CH:54]=[CH:55][CH:56]=2)[CH:36]1[OH:72])[CH2:32][CH2:33][CH3:34]

Participants

4

Reactant 2

HCID 18374567HCID 18374567, compoundHCID 18374571HCID 18374571, compound

Product 1

HCID 12109773HCID 12109773, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Preparation analogous to example II, starting from 83 mg of 4-(4-aminomethylphenyl)-1-(4-fluorophenyl)-3-(3-hydroxy-3-phenylpropyl)azetidin-2-one and 130 mg of [2-(2-{[3-(3-butyl-7-dimethylamino-3-ethyl-4-hydroxy-1,1-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]thiepin-5-yl)phenylcarbamoyl]methoxy}ethoxy)ethoxy]acetic acid; chromatography: SiO2, dichloromethane/methanol=20:1; product of melting point 120° C. and molecular weight 1021.3 (C57H67FN4O10S); MS (ESI+): 1021 (M+H+).

Workup

  1. customPreparation analogous to example II

Sources & evidence

ORD record
ord-d78c89611d3e4a6e90cd06e4a32b0754
Source dataset
uspto-grants-2002_12
Patent number
US06498156B2

Reaction notes

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