1-Phenethylamine, (+)- → HCID 45486762, compound

HRID 2300720Notes

Reaction equation

HRID 2300720 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[C:20]1([C@H:26]([NH2:28])[CH3:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([C@H:26]([NH:28][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH3:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 6431891-Phenethylamine, (+)-HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 45486762HCID 45486762, compound

Procedure

2-methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with (R)-1-phenylethylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (CI): m/e 316.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.49 (br s, 1H); 8.37 (d, J=5.1 Hz, 1H); 7.83 (d, J=8.0 Hz, 1H); 7.3-7.5 (m, 8H); 6.77 (d, J=5.3 Hz, 1H); 6.03 (br s, 1H); 5.22 (br s, 1H); 1.65 (d, J=7.0 Hz, 3H).

Sources & evidence

ORD record
ord-28a6aa9d76a9454c885374a10098e20d
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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