2,3-Dichlorobenzylamine → HCID 18375922, compound

HRID 2300725Notes

Reaction equation

HRID 2300725 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[Cl:20][C:21]1[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH2:24]>>[Cl:20][C:21]1[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH:24][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 5876252,3-DichlorobenzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375922HCID 18375922, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 2,3-dichlorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 370.1 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.58 (s, 1H); 8.44 (d, J=5.5 Hz, 1H); 7.93 (br s, 1H); 7.85 (d, J=8.3 Hz, 1H); 7.19 (t, J=5.8 Hz, 1H); 6.86 (d, J=5.5 Hz, 1H); 5.88 (br s, 1H); 4.86 (d, J=6.4 Hz, 2H).

Sources & evidence

ORD record
ord-9230e3fa32114014ae83d95a86f894fb
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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