2-Methoxybenzylamine → HCID 18375810, compound

HRID 2300734Notes

Reaction equation

CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH3:20][O:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][NH2:25]>>[CH3:20][O:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][NH:25][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

Reactant 2

HCID 812922-Methoxybenzylamine

HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375810HCID 18375810, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 2-methoxybenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 332.1 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.63 (s, 1H); 8.41 (br s, 1H); 8.12 (br s, 1H); 7.86 (m, 1H); 6.94 (m, 2H); 6.79 (d, J=5.2 Hz, 1H); 5.95 (br s, 1H); 4.74 (d, J=5.9 Hz, 2H); 3.92 (s, 3H).

Sources & evidence

ORD record: ord-46ca2d9a7e954fbd831b5eaf1b597f1f
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06498165B1

Reaction notes

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