4-Fluorobenzylamine → HCID 18375885, compound

HRID 2300737Notes

Reaction equation

HRID 2300737 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH:26][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 673264-FluorobenzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375885HCID 18375885, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 4-fluorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 320.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.60 (s, 1H); 8.43 (br s, 1H); 8.07 (br s, 1H); 7.86 (m, 1H); 7.38 (m, 5H); 7.07 (t, J=8.7 Hz, 1H); 6.85 (d, J=5.5 Hz, 1H); 5.79 (br s, 1H); 4.72 (d, J=5.7 Hz, 2H).

Sources & evidence

ORD record
ord-0ad0d87eb658498aada1abdc82e388fb
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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