4-(Trifluoromethoxy)benzylamine → HCID 18375573, compound

HRID 2300738Notes

Reaction equation

HRID 2300738 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[F:20][C:21]([F:32])([F:31])[O:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1>>[F:20][C:21]([F:31])([F:32])[O:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375573HCID 18375573, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 4-trifluoromethoxybenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 386.2 (M+1). 1H NMR (500 MHz, CDCl3): d partial 8.59 (s, 1H); 8.44 (br s, 1H); 8.02 (br s, 1H); 7.86 (d, J=8.3 Hz, 1H); 7.45 (d, J=8.4 Hz, 2H); 7.24 (d, J=8.3 Hz, 1H); 6.87 (d, J=5.2 Hz, 1H); 5.84 (br s, 1H); 4.76 (d, J=6.1 Hz, 2H).

Sources & evidence

ORD record
ord-8493f9cb8f4b4d4e8b51bd079c3578ac
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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