4-(Trifluoromethoxy)benzylamine → HCID 18375573, compound

Participants

Reaction Steps

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 4-trifluoromethoxybenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 386.2 (M+1). 1H NMR (500 MHz, CDCl3): d partial 8.59 (s, 1H); 8.44 (br s, 1H); 8.02 (br s, 1H); 7.86 (d, J=8.3 Hz, 1H); 7.45 (d, J=8.4 Hz, 2H); 7.24 (d, J=8.3 Hz, 1H); 6.87 (d, J=5.2 Hz, 1H); 5.84 (br s, 1H); 4.76 (d, J=6.1 Hz, 2H).

Provenance & Evidence