3-(Trifluoromethyl)benzylamine → 2-[3-Trifluoromethylbenzylamino]-4-[benzimidazol-1-yl]pyrimidine

HRID 2300739Notes

Reaction equation

HRID 2300739 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[F:20][C:21]([F:31])([F:30])[C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH2:26]>>[F:20][C:21]([F:30])([F:31])[C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH:26][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 183756192-[3-Trifluoromethylbenzylamino]-4-[benzimidazol-1-yl]pyrimidine

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3-trifluoromethylbenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 370.2 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.58 (br s, 1H); 8.39 (br s, 1H); 7.85 (d, J=8.2 Hz, 1H); 7.69 (s, 1H); 7.61 (d, J=7.6 Hz, 1H); 7.57 (d, J=7.6 Hz, 1H); 7.49 (m, 1H); 6.85 (d, J=5.3 Hz, 1H); 6.38 (br s, 1H); 4.81 (d, J=6.2 Hz, 2H).

Sources & evidence

ORD record
ord-0227a500fab8422ca72b0bb2aa5f60ec
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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