3-(Trifluoromethyl)benzylamine → 2-[3-Trifluoromethylbenzylamino]-4-[benzimidazol-1-yl]pyrimidine

Participants

Reaction Steps

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3-trifluoromethylbenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 370.2 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.58 (br s, 1H); 8.39 (br s, 1H); 7.85 (d, J=8.2 Hz, 1H); 7.69 (s, 1H); 7.61 (d, J=7.6 Hz, 1H); 7.57 (d, J=7.6 Hz, 1H); 7.49 (m, 1H); 6.85 (d, J=5.3 Hz, 1H); 6.38 (br s, 1H); 4.81 (d, J=6.2 Hz, 2H).

Provenance & Evidence