2-Fluorobenzylamine → HCID 18375438, compound

HRID 2300741Notes

Reaction equation

CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[F:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH2:24]>>[F:20][C:21]1[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=1[CH2:23][NH:24][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

Reactant 2

HCID 666492-Fluorobenzylamine

HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375438HCID 18375438, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 2-fluorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 320.1 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.62 (s, 1H); 8.43 (br s, 1H); 8.09 (br s, 1H); 7.86 (m, 1H); 7.13 (m, 2H); 6.85 (d, J=5.3 Hz, 1H; 5.87 (br s, 1H); 4.81 (d, J=6.1 Hz, 2H).

Sources & evidence

ORD record: ord-22e57a01211c49d7b49e506f67030ac1
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06498165B1

Reaction notes

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