3-Fluorobenzylamine → HCID 18375513, compound

HRID 2300746Notes

Reaction equation

HRID 2300746 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH2:25]>>[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH:25][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 668533-FluorobenzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375513HCID 18375513, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3-fluorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 320.2 (M+1). 1H NMR (500 MHz, CD3OD): δ partial 8.84 (br s, 1H); 8.39 (d, J=5.5 Hz, 1H); 7.97 (br s, 1H); 7.71 (d, J=8.2 Hz, 1H); 7.13 (d, J=10.1 Hz, 1H); 7.06 (d, J=5.5 Hz, 1H); 6.96 (m, 1H); 4.69 (s, 2H).

Sources & evidence

ORD record
ord-5b282cc9680348d48337cadeb3fd5680
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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