Benzenemethanamine, 3-bromo- → HCID 18375621, compound

HRID 2300747Notes

Reaction equation

HRID 2300747 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[Br:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH2:25]>>[Br:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH:25][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 457587Benzenemethanamine, 3-bromo-HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375621HCID 18375621, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3-bromobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 380.2, 382.2 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.58 (s, 1H); 8.44 (d, J=5.3 Hz, 1H); 8.01 (br s, 1H); 7.85 (m, 1H); 7.58 (s, 1H); 7.45 (d, J=7.5 Hz, 1H); 6.87 (d, J=5.5 Hz, 1H); 5.83 (br s, 1H); 4.74 (d, J=6.1 Hz, 2H).

Sources & evidence

ORD record
ord-886f9fa5044a4b8d80565fe8ce0576d5
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

Loading…