3,5-Difluorobenzylamine → HCID 18375442, compound

HRID 2300749Notes

Reaction equation

HRID 2300749 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[C:27]([F:29])[CH:28]=1)[CH2:24][NH2:25]>>[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[C:27]([F:29])[CH:28]=1)[CH2:24][NH:25][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 1452113,5-DifluorobenzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375442HCID 18375442, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3,5-difluorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 338.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.58 (s, 1H); 8.45 (d, J=5.5 Hz, 1H); 7.98 (br s, 1H); 7.85 (d, J=8.5 Hz, 1H); 7.36 (m, 2H); 6.95 (d, J=6.4 Hz, 2H); 6.89 (d, J=5.4 Hz, 1H); 6.74 (m, 1H); 5.87 (br s, 1H); 4.75 (d, J=6.4 Hz, 2H).

Sources & evidence

ORD record
ord-7ba2e8b822424653941660c5ed6698c9
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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