3-Iodobenzylamine → HCID 18375844, compound

HRID 2300751Notes

Reaction equation

HRID 2300751 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[I:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH2:25]>>[I:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH:25][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 970123-IodobenzylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375844HCID 18375844, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3-iodobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 428.1 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.59 (s, 1H); 8.44 (d, J=4.7 Hz, 1H); 8.02 (br s, 1H); 7.86 (m, 1H); 7.79 (s, 1H); 7.65 (d, J=7.8 Hz, 1H); 7.38 (m, 3H); 7.12 (t, J=7.8 Hz, 1H), 6.87 (d, J=5.3 Hz, 1H); 5.78 (br s, 1H); 4.71 (d, J=5.9 Hz, 2H).

Sources & evidence

ORD record
ord-8716893357f94aaaaa93bc0e9f1058e2
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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