4-Chlorobenzylamine → HCID 18375927, compound

HRID 2300754Notes

Reaction equation

CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[Cl:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH:26][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 660364-Chlorobenzylamine

HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375927HCID 18375927, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 4-chlorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 336.0 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.59 (s, 1H); 8.43 (d, J=4.6 Hz, 1H); 8.02 (br s, 1H); 7.86 (m, 1H); 6.86 (d, J=5.5 Hz, 1H); 5.79 (br s, 1H ); 4.73 (d, J=5.9 Hz, 2H).

Sources & evidence

ORD record: ord-2e87a20cbead4c43bb5f87ce27ed81d5
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06498165B1

Reaction notes

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