1-Naphthalenemethanamine, alpha-methyl-, (alphaS)- → HCID 59924679, compound

HRID 2300755Notes

Reaction equation

HRID 2300755 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[C:20]1([C@@H:30]([NH2:32])[CH3:31])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1>>[C:20]1([C@@H:30]([NH:32][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH3:31])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 663251-Naphthalenemethanamine, alpha-methyl-, (alphaS)-HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 59924679HCID 59924679, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with (S)-1-(1-naphthyl)ethylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 366.1 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.40 (d, J=4.6 Hz, 1H); 8.34 (br s, 1H); 8.23 (d, J=8.2 Hz, 1H); 7.97 (d, J=7.6 Hz, 1H); 7.82 (d, J=8.2 Hz, 1H); 7.67 (d, J=6.9 Hz, 1H); 7.47 (t, J=7.7 Hz, 1H); 6.77 (s, 1H); 6.03 (br s, 2H); 1.80 (d, J=6.7 Hz, 3H).

Sources & evidence

ORD record
ord-ba4d21ae1f824754867220eca35113a4
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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