(1S)-1-phenylpropan-1-amine → HCID 59924874, compound

HRID 2300756Notes

Reaction equation

HRID 2300756 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[C:20]1([C@@H:26]([NH2:29])[CH2:27][CH3:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([C@@H:26]([NH:29][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH2:27][CH3:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 6993773(1S)-1-phenylpropan-1-amineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 59924874HCID 59924874, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with (S)-1-phenylpropylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 330.3 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.49 (br s, 1H); 8.38 (d, J=5.5 Hz, 1H); 7.83 (d, J=7.6 Hz, 1H); 7.27-7.44 (m, 6H); 6.77 (d, J=5.5 Hz, 1H); 5.88 (br s, 1H); 4.97 (br s, 1H); 1.97 (m, 2H); 1.03 (t, J=7.5 Hz, 3H).

Sources & evidence

ORD record
ord-32b1f7edf8c44ea0ad8b759599b73dd5
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

Loading…