2-Amino-2-phenylethan-1-ol → HCID 69963118, compound

HRID 2300757Notes

Reaction equation

HRID 2300757 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[C:20]1([C@H:26]([NH2:29])[CH2:27][OH:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([C@H:26]([NH:29][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH2:27][OH:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 1347972-Amino-2-phenylethan-1-olHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 69963118HCID 69963118, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with (S)-1-phenyl-2-hydroxyethylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (CI): m/e 332.2 (M+1). 1H NMR (500 Mz, CD3OD): δ partial 8.58 (br s, 1H); 8.38 (s, 1H); 7.69 (d, J=7.3 Hz, 1H); 7.47 (d, J=7.3 Hz, 2H); 7.02 (d, J=5.5 Hz, 1H); 5.16 (s, 1H); 3.81-3.91 (m, 2H).

Sources & evidence

ORD record
ord-a4d275f265d941a8ae7ecfe3843f62a0
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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