Tert-Butylamine → HCID 18375735, compound

HRID 2300758Notes

Reaction equation

CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH3:20][C:21]([NH2:24])([CH3:23])[CH3:22]>>[CH3:20][C:21]([NH:24][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)([CH3:23])[CH3:22]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375735HCID 18375735, compound

Conditions

Temperature: 40 °C

Procedure

The title compound was prepared from 2-methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine according to the procedure described in EXAMPLE 1, Step C except using 1,1-dimethylethylamine as the solvent and heating at 40° C. Mass Spectrum (CI): m/e 268.3 (M+1). ). 1H NMR (500 MHz, CDCl3): δ 8.69 (s, 1H); 8.40 (d, J=5.5 Hz, 1H); 8.07 (d, J=7.3 Hz, 1H); 7.88 (m, 1H); 7.40 (m, 2H); 6.81 (d, J=5.2 Hz, 1H); 5.40 (br s, 1H); 1.54 (s, 9H).

Sources & evidence

ORD record: ord-9b9bb7b3d1b6448b99d82154cb0148eb
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06498165B1

Reaction notes

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