(S)-(+)-1-Cyclohexylethylamine → HCID 45486772, compound

HRID 2300761Notes

Reaction equation

HRID 2300761 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH:20]1([C@@H:26]([NH2:28])[CH3:27])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH:20]1([C@@H:26]([NH:28][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH3:27])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 5325951(S)-(+)-1-CyclohexylethylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 45486772HCID 45486772, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with (S)-1-cyclohexylethylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): 322.3 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.63 (s, 1H); 8.30 (br s, 1H); 8.23 (br s, 1H); 7.88 (d, J=7.3 Hz, 1H); 7.43 (m, 2H); 6.80 (d, J=5.2 Hz, 1H); 4.10 (m, 1H); 1.69-1.91 (m, 4H); 1.10-1.35 (m, 10H).

Sources & evidence

ORD record
ord-118d7cc506734b01a6577068aa2fb53f
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

Loading…