Sodium hydride → HCID 69782740, compound

HRID 2300968Notes

Reaction equation

HRID 2300968 reaction equation
[H-].[Na+].[CH3:3][O:4][C:5](=[O:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:9][CH:8]=1>C(=O)(OC)OC>[CH3:3][O:4][C:5](=[O:21])[CH:6]([C:7]1[CH:8]=[CH:9][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:11][CH:12]=1)[C:5]([O:4][CH3:3])=[O:21]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 12531835HCID 12531835, compound

Product 1

HCID 69782740HCID 69782740, compound

Reagents, catalysts & solvents 1

HCID 12021Dimethyl CarbonateSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of sodium hydride (350 mg) in dimethyl carbonate (10 ml) was treated at room temperature with the product obtained in step D. The mixture was heated to 90° C. for 1 hour, cooled and poured into ice water and extracted with methylene chloride. The extract was dried and evaporated to yield 5.7 of the title compound as an oil.

Workup

  1. temperaturecooled
  2. extractionextracted with methylene chloride
  3. customThe extract was dried
  4. customevaporated

Sources & evidence

ORD record
ord-2175ca1a40664e39ac1b4068f2b08522
Source dataset
uspto-grants-2002_12
Patent number
US06498252B1

Reaction notes

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