反应详情

温度

90 °C

To a mixture of 10.2 g of dibenzylamine and 29.7 g of water, 8.9 g of 37% by weight formaldehyde aqueous solution was added dropwise at room temperature, followed by dropwise addition of 12.8 g of 3-acetyltetrahydrofuran-2-one at room temperature. After the completion of addition, the mixture was heated to 90° C. and thereby yielded a solution. The solution was cooled to room temperature, was filtrated, the resulting solid matter was heated with diethyl ether and thereby yielded a solution. The solution was gradually cooled to 0° C., the resulting crystal was filtrated and thereby yielded 19.2 g of 3-acetyl-N,N-dibenzyl-3-aminomethyltetrahydrofuran-2-one as a white crystal.

1. additionwas added dropwise at room temperature
2. additionAfter the completion of addition
3. customyielded a solution
4. temperatureThe solution was cooled to room temperature
5. filtrationwas filtrated
6. temperaturethe resulting solid matter was heated with diethyl ether
7. customyielded a solution
8. temperatureThe solution was gradually cooled to 0° C.
9. filtrationthe resulting crystal was filtrated