Formaldehyde → 3-acetyl-N,N-dibenzyl-3-aminomethyltetrahydrofuran-2-one

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To a mixture of 10.2 g of dibenzylamine and 29.7 g of water, 8.9 g of 37% by weight formaldehyde aqueous solution was added dropwise at room temperature, followed by dropwise addition of 12.8 g of 3-acetyltetrahydrofuran-2-one at room temperature. After the completion of addition, the mixture was heated to 90° C. and thereby yielded a solution. The solution was cooled to room temperature, was filtrated, the resulting solid matter was heated with diethyl ether and thereby yielded a solution. The solution was gradually cooled to 0° C., the resulting crystal was filtrated and thereby yielded 19.2 g of 3-acetyl-N,N-dibenzyl-3-aminomethyltetrahydrofuran-2-one as a white crystal.

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