Formaldehyde → HCID 12052017, compound

Participants

Reaction Conditions

Reaction Steps

To 59.4 g of water, 21.4 g of benzylamine was added, and the resulting mixture was stirred with 17.8 g of 37% by weight formaldehyde aqueous solution at room temperature for 1 hour. To the mixture, 25.6 g of 3-acetyltetrahydrofuran-2-one was added dropwise, followed by stirring at 60° C. for 1 hour. After the completion of reaction, the resulting mixture was cooled to room temperature, followed by removal of water from the resulting oily matter, and thereby yielded 23.6 g of 3-acetyl-N-benzyl-3-aminomethyltetrahydrofuran-2-one as a yellow oily matter.

Provenance & Evidence