Formaldehyde → HCID 12052017, compound

HRID 2301000Notes

Reaction equation

HRID 2301000 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:9]=O.[C:11]([CH:14]1[CH2:18][CH2:17][O:16][C:15]1=[O:19])(=[O:13])[CH3:12]>O>[C:11]([C:14]1([CH2:9][NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:18][CH2:17][O:16][C:15]1=[O:19])(=[O:13])[CH3:12]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 7504BenzylamineHCID 106012-Acetylbutyrolactone

Product 1

HCID 12052017HCID 12052017, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

To 59.4 g of water, 21.4 g of benzylamine was added, and the resulting mixture was stirred with 17.8 g of 37% by weight formaldehyde aqueous solution at room temperature for 1 hour. To the mixture, 25.6 g of 3-acetyltetrahydrofuran-2-one was added dropwise, followed by stirring at 60° C. for 1 hour. After the completion of reaction, the resulting mixture was cooled to room temperature, followed by removal of water from the resulting oily matter, and thereby yielded 23.6 g of 3-acetyl-N-benzyl-3-aminomethyltetrahydrofuran-2-one as a yellow oily matter.

Workup

  1. customAfter the completion of reaction
  2. temperaturethe resulting mixture was cooled to room temperature
  3. customfollowed by removal of water from the resulting oily matter

Sources & evidence

ORD record
ord-bd18378f9f484feca2046112e7986874
Source dataset
uspto-grants-2002_12
Patent number
US06498258B2

Reaction notes

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