Hydrazine hydrate (1:1) → HCID 24851119, compound

HRID 230103Notes

Reaction equation

HRID 230103 reaction equation
[C:1]([C:4]1[N:8]=[CH:7][NH:6][C:5]=1[C:9]#[N:10])(=O)[CH3:2].O.[NH2:12][NH2:13]>C(O)C>[NH2:10][C:9]1[N:13]=[N:12][C:1]([CH3:2])=[C:4]2[N:8]=[CH:7][NH:6][C:5]=12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178467459HCID 178467459, compound

Product 1

HCID 24851119HCID 24851119, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2.00 g 5-acetyl-3H-imidazole-4-carbonitrile and 4.00 ml hydrazine hydrate in 50 ml of ethanol is heated to 100° C., until the reaction is complete according to HPLC-MS. After cooling to ambient temperature the reaction mixture is evaporated down, stirred with 20 ml of cold ethanol and suction filtered. The filter cake is washed with diethyl ether and dried.

Workup

  1. temperatureAfter cooling to ambient temperature the reaction mixture
  2. customis evaporated down
  3. filtrationfiltered
  4. washThe filter cake is washed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-e81e1d3868ad490da7a0c6333893de60
Source dataset
uspto-grants-2009_07
Patent number
US07566707B2

Reaction notes

Loading…